Erkam Tüzgen completed his undergraduate education at Çanakkale 18 Mart University, Faculty of Medicine in 2012. He worked as a Community Health Center physician, Deputy Provincial Health Director, Provincial Health, and Public Health Director respectively in Hakkari between December 2012 and May 2014. Besides the reforms he introduced during his time in Hakkari, he was the first in Türkiye to implement the remote candidate civil servant training, which is now widely used. He then served as District Health Director in Beşiktaş and Üsküdar. He worked as the Deputy Director of the Istanbul Provincial Health Directorate and Chairman of the Istanbul Organ Transplantation Ethics Commission between April 2015 and November 2016.

He served as the founding Secretary General at Ibn Haldun University between December 2016 and May 2020 and as the Secretary General of Istanbul Development Agency between May 2020 and November 2023. He has initiated over 200 projects within the Development Agency. He realized the first Social Impact Bond contract in Türkiye. He led the Regional Venture Fund program, the first among development agencies, to invest on behalf of the public in 10 different funds established in four countries. He served as a Board Member of the European Development Agencies Association between 2021-2023.

Serving as the General Manager of Bilişim Vadisi since November 30, 2023, Tüzgen is married to Nagehan Pakdamar Tüzgen and is the father of Eslem, Benan, and Selman.